Effect of Apatinib Combined with mFOLFOX6 Chemotherapy on Therapeutic Effect and Serum Tumor Markers in Patients with Stage ⅢB,Stage Ⅳ Gastric Cancer
Objective:To explore the effec of Apatinib combined with mFOLFOX6 chemotherapy(Calcium Folinate,Fluorouracil and Oxaliplatin)on therapeutic effect and serum tumor markers in patients with stage ⅢB,stage Ⅳ gastric cancer.Method:A total of 102 patients with stage ⅢB,stage Ⅳ gastric cancer who admitted to Jingjiang People's Hospital from December 2017 to October 2019 were selected as the research objects,the patients were divided into the combined group(Apatinib combined with mFOLFOX6 chemotherapy)and the reference group(mFOLFOX6 chemotherapy)by random number table method,with 51 cases in each group.The therapeutic effect,vascular endothelial growth factor(VEGF)and insulin-like growth factor 1(IGF-1),survival time and adverse reactions were compared between two groups.Result:The total effective rate in the combined group was higher than that in the reference group,the difference was statistically significant(P<0.05);after treatment,the levels of serum IGF-1 and VEGF in two groups were lower than those before treatment,and those in the combined group were lower than those in the reference group,the differences were statistically significant(P<0.05);the total average survival time of the combined group was longer than that of the reference group,and the difference was statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Apatinib combined with mFOLFOX6 chemotherapy has significant efficacy in patients with stage ⅢB,stage Ⅳ gastric cancer,it can significantly decrease serum IGF-1 and VEGF levels,prolong the total mean survival time,and is safe and reliable.
ApatinibCalcium FolinateFluorouracilOxaliplatinGastric cancerVascular endothelial growth factorInsulin like growth factor 1
万方数据
维普
