Effect of Bazhen Decoction and Huaji Pills Combined with Nucleoside Drugs in the Treatment of"Positive Deficiency and Blood Stasis Type"Hepatitis B Cirrhosis and Secondary Hypersplenism
Objective:To explore clinical effect of Bazhen Decoction and Huaji Pills combined with nucleoside drugs in the treatment of"positive deficiency and blood stasis type"hepatitis B cirrhosis and secondary hypersplenism.Method:From June to December 2020,96 patients who diagnosed as"hepatitis B cirrhosis and secondary hypersplenism"by western medicine and"positive deficiency and blood stasis type"by traditional Chinese medicine syndrome differentiation in Wuwei City Liangzhou Hospital were selected as the research objects,they were divided into the control group and the observation group according to the random number table method,48 cases in each group.The control group was given Tenofovir Dipivoxil,and the observation group was given Tenofovir Dipivoxil combined with Bazhen Decoction and Huaji Pills.The white blood cell(WBC),platelet(PLT),prothrombin activity(PTA),spleen thickness,portal vein diameter,liver hardness and clinical efficacy of two groups were compared.Result:Before treatment and 3 months after treatment,there were no significant differences in WBC,PLT,PTA levels,spleen thickness and portal vein diameter between two groups(P>0.05);at 6 months of treatment,the levels of WBC,PLT and PTA in two groups were higher than those before treatment,the spleen thickness and portal vein diameter were lower than those before treatment,and those in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in liver FibroScan elasticity value between two groups before treatment(P>0.05);the liver FibroScan elasticity value of the observation group at 6 months of treatment was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 87.5%,which was higher than 62.5%of the control group,the difference was statistically significant(P<0.05).Conclusion:Bazhen Decoction and Huaji Pills combined with nucleoside drugs in the treatment of"positive deficiency and blood stasis type"hepatitis B cirrhosis and secondary hypersplenism can not only improve the clinical symptoms,but also increase the WBC and PLT,and improve PTA,and have significant effects in reducing the liver hardness value,the thickness of the spleen and the diameter of portal vein.
Bazhen Decoction and Huaji PillsNucleoside drugsHepatitis B cirrhosisSecondary hypersplenism
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