Effect of Esketamine-induced Sleep on Respiratory and Airway Obstruction
Objective:To investigate the effects of Esketamine-induced sleep on respiratory and airway obstruction in patients.Method:A total of 60 patients who were to underwent drug-induced sleep examination in Guangdong Provincial People's Hospital Zhuhai Hospital from January to June 2021 were selected and randomly divided into group Ⅰ and group Ⅱ by random number method,with 30 patients in each group.Group Ⅰ was given Esketamine to induce sleep,group Ⅱ was given Midazolam to induce sleep.After falling asleep,the patients were monitored for airway obstruction in supine position with fibrolaryngoscope.Ramsay sedation score,respiratory rate(RR),minimum oxygen saturation(SpO2)before medication(T0),5 min after medication(T1),10 min after medication(T2),20 min after medication(T3)and 30 min after medication(T4),sleep-induced breathing monitoring indicators,airway obstruction and adverse reaction were recorded.Result:At T1-T4,there were no significant differences in Ramsay sedation score between the two groups(P>0.05).At T1-T4,SpO2 in both groups were lower than that at T0,and the differences were statistically significant(P<0.05).At T2-T4,SpO2 in group Ⅱwas lower than that in group Ⅰ,and the difference was statistically significant(P<0.05).At T2-T4,RR of group Ⅰ was lower than that of T0,at T1-T4,RR of group Ⅱ was lower than that of T0,and the differences were statistically significant(P<0.05).At T1-T4,RR in group Ⅱwere lower than those in group Ⅰ,and the differences were statistically significant(P<0.05).During 30 min of drug-induced sleep,apnea-hypopnea index(AHI)and number of apnea in group Ⅰ were significantly lower than those in group Ⅱ,and the minimum SpO2,RR was significantly higher than that in group Ⅱ,the differences were statistically significant(P<0.05).The proportion of patients without stenosis in group Ⅰ was higher than that in group Ⅱ,and the proportion of patients with type Ⅳ stenosis was lower than that in group Ⅱ,the differences were statistically significant(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Esketamine-induced sleep had lower incidence of respiratory depression and airway obstruction.
万方数据
维普
