目的:探讨重组人尿激酶原注射辅助急诊经皮冠状动脉介入术(percutaneous coronary intervention，PCI)治疗急性ST段抬高型心肌梗死(ST-elevation myocardial infarction，STEMI)的效果及对心肌微循环指标、心功能的影响。方法:选取 2021 年 7 月—2022 年 12 月重庆市开州区人民医院收治的 84 例急性STEMI患者作为研究对象，按照随机数表法将患者分为对照组和观察组，各 42 例。对照组给予急诊PCI治疗，观察组于对照组基础上加用重组人尿激酶原注射治疗。比较两组临床疗效、心肌微循环指标、心功能及不良事件。结果:观察组临床总有效率高于对照组，差异有统计学意义(P<0。05);治疗后，两组磷酸肌酸同工酶(creatine kinase-MB，CK-MB)峰值、CK-MB峰值时间、左室收缩末期内径(left ventricular end systolic diameter，LVESD)、左室收缩末期容积(left ventricular end systolic volume，LVESV)、左室舒张末期内径(left ventricular end diastolic dimension，LVEDD)均低于治疗前，且观察组低于对照组，差异有统计学意义(P<0。05);观察组不良事件总发生率与对照组比较，差异无统计学意义(P>0。05)。结论:重组人尿激酶原注射辅助急诊PCI治疗急性STEMI患者的效果确切，能有效改善心肌微循环指标，促进心功能提升，且安全性高。
Effect of Recombinant Human Urokinase Injection Assisted Emergency PCI in the Treatment of Acute STEMI Patients and Its Influence on Myocardial Microcirculation Index and Cardiac Function
Objective:To investigate the effect of Recombinant Human Urokinase injection assisted emergency percutaneous coronary intervention(PCI)in the treatment of acute ST-elevation myocardial infarction(STEMI)and its influence on myocardial microcirculation index and cardiac function.Method:A total of 84 acute STEMI patients who admitted to Kaizhou District People's Hospital of Chongqing from July 2021 to December 2022 were selected as the study objects,and they were randomly divided into the control group and the observation group,42 cases in each group.The control group was given emergency PCI,and the observation group was given Recombinant Human Urokinase injection on the basis of the control group.The clinical efficacy,myocardial microcirculation index,cardiac function and adverse events of two groups were compared.Result:The total effective rate of the observation group was higher than that of control group,the difference was statistically significant(P<0.05).After treatment,the creatine kinase-MB(CK-MB)peak value,CK-MB peak time,left ventricular end systolic diameter(LVESD),left ventricular end systolic volume(LVESV),left ventricular end diastolic dimension(LVEDD)levels in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse events in observation group and control group were compared,the difference was not statistically significant(P>0.05).Conclusion:Recombinant Human Urokinase injection assisted emergency PCI is effective in the treatment of acute STEMI,which can effectively improve myocardial microcirculation indexe and promote cardiac function,and has high safety.
Acute ST-elevation myocardial infarctionPercutaneous coronary interventionRecombinant Human UrokinaseClinical efficacyMyocardial microcirculationCardiac function
国家科技期刊平台
NSTL
万方数据
维普
