Influence of Ultrasound-guided Femoral Nerve Block Combined with General Anesthesia for Pain and Inflammatory Reactions of Patients with Total Knee Arthroplasty
Objective:To explore the effects of ultrasound-guided femoral nerve block combined with general anesthesia on pain and inflammation in patients with total knee replacement.Method:A total of 100 total knee replacement patients admitted to Ningde Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine from January 2021 to December 2022 were selected.They were divided into control group and observation group according to random number table method,with 50 cases in each group.The control group received general anesthesia intervention,and the observation group received ultrasound-guided femoral nerve block combined with general anesthesia intervention.The incidence of adverse reactions,pain scores[visual analogue score(VAS)],mechanical pain threshold,pain factors[serum substance P(SP),prostaglandin E2(PGE2)]and inflammatory response indicators[serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]before and after surgery were compared between the two groups.Result:There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Before surgery,there were no significant differences in VAS score at rest and exercise,mechanical pain threshold,pain factor and inflammatory response index between the two groups(P>0.05).At 2 h,6 h,12 h and 24 h after surgery,the VAS score at rest and exercise in the observation group were significantly lower than those in the control group,and the mechanical pain threshold were significantly higher than those in the control group,the differences were statistically significant(P<0.05).At 12 h,24 h and 48 h after surgery,SP,PGE2,CRP and TNF-α in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:Ultrasound-guided femoral nerve block combined with general anesthesia can effectively control the pain degree of patients with total knee replacement,and can significantly improve the pain and inflammation response.
国家科技期刊平台
NSTL
万方数据
维普
