Effect of rPA Thrombolysis on Myocardial Reperfusion,Vascular Recanalization Rate and Platelet Activation Function in Patients with Acute Myocardial Infarction
Objective:To evaluate the effects of Reteplase(rPA)thrombolytic therapy on myocardial reperfusion,vascular revascularization rate and platelet activation in patients with acute myocardial infarction(AMI).Method:A total of 232 patients with AMI treated in Zouping People's Hospital from February 2020 to January 2022 were randomly divided into rPA group and UK group,with 116 patients in each group.rPA group was given rPA intravenous therapy,UK group was given Urokinase(UK)intravenous therapy,and all patients were treated for 5-7 d.Myocardial reperfusion,vascular revascularization rate and platelet activation indexes were compared between the two groups.Result:After treatment,left ventricular ejection fraction(LVEF),cardiac troponin I(cTnI)and creatine kinase isoenzyme(CK-MB)in both groups were higher than those before treatment,CK-MB and cTnI in rPA group were lower than those in UK group,and LVEF was higher than that in UK group,the differences were statistically significant(P<0.05).The vascular revascularization rate in rPA group after thrombolytic therapy was significantly higher than that in UK group,and the difference was statistically significant(P<0.05).After treatment,the monocyte platelet aggregates(MPA),platelet α particle surface membrane glycoprotein(CD62p)and lysosomal membrane glycoprotein(CD63)in both groups were lower than those before treatment,and MPA,CD62p and CD63 in rPA group were lower than those in UK group,and the differences were statistically significant(P<0.05).Conclusion:The use of rPA for thrombolytic therapy in AMI patients can significantly improve the vascular patency rate,myocardial reperfusion,and platelet activation function.
国家科技期刊平台
NSTL
万方数据
维普
