白藜芦醇治疗神经系统疾病的机制研究
Study on Mechanism of Resveratrol in the Treatment of Neurological Diseases
王凌昊 1张存鑫 2吕超亮 2李康2
作者信息
- 1. 济宁医学院临床学院 山东 济宁 272067
- 2. 济宁市第一人民医院
- 折叠
摘要
白藜芦醇(Resveratrol,RSV)是一种天然多酚,具有抗氧化、抗炎、调节自噬及凋亡、调节内质网应激等多种药理特性,故对多种神经系统疾病具有潜在的治疗价值,如脊髓损伤、创伤性脑损伤、帕金森病和阿尔茨海默病等.RSV的治疗机制在不同疾病中不尽相同,本文通过文献研究法进行归纳梳理,RSV对神经系统的保护作用主要包括以下方面:(1)调节氧化应激水平;(2)抑制炎症反应;(3)激活自噬和减少凋亡;(4)调节内质网应激等.本文旨在总结RSV在治疗神经系统疾病中的分子机制,为神经系统疾病的药物治疗提供新思路.
Abstract
Resveratrol(RSV)is a natural polyphenol with a variety of pharmacological properties,including antioxidant,anti-inflammatory,regulating autophagy and apoptosis,and regulating endoplasmic reticulum stress,and therefore has potential therapeutic value in a variety of neurological diseases,such as spinal cord injury,traumatic brain injury,Parkinson disease and Alzheimer's disease,etc.The therapeutic mechanism of RSV varies in different diseases,this paper summarized through the literature research method,the protective effects of RSV on the nervous system include the following aspects:(1)regulation of oxidative stress levels;(2)inhibition of inflammatory responses;(3)activation of autophagy and reduction of apoptosis;(4)regulation of endoplasmic reticulum stress.This paper aims to summarize the molecular mechanism of RSV in the treatment of neurological diseases,and provide new ideas for the drug treatment of neurological diseases.
关键词
白藜芦醇/神经系统疾病/神经保护/氧化应激/炎症反应/自噬及凋亡/内质网应激Key words
Resveratrol/Neurological diseases/Neuroprotection/Oxidative stress/Inflammatory response/Autophagy and apoptosis/Endoplasmic reticulum stress引用本文复制引用
基金项目
山东省卫生健康委面上项目(2020M153)
山东省中医药科技项目(Q-2022025)
济宁市重点研发计划(2021YXNS001)
济宁市重点研发计划(2022YXNS114)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据