Predictive Value of Serum Cystatin C and N-terminal Pro-B-type Natriuretic Peptide in Chronic Kidney Disease Combined with Heart Failure
Objective:To investigate the efficacy of serum cystatin C(Cys C)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in predicting chronic kidney disease(CKD)combined with heart failure(HF).Method:A retrospective study was conducted on the medical records of 70 CKD patients who visited the Seventh Hospital of Wuhan from June 2020 to June 2022.They were divided into occurrence group(18 cases,with HF)and non occurrence group(52 casese,without HF)based on whether HF occurred within one year after the patients'visit.The baseline data and laboratory indexes were compared between the two groups.The relationship between Cys C,NT-proBNP and CKD combined with HF was analyzed.The value of serum Cys C and NT-proBNP in predicting CKD complicated with HF was discussed by receiver operating characteristic(ROC)curve.Result:The proportion of CKD stages 3 and 4,Cys C and NT-proBNP levels in the occurrence group were significantly higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).Point two-column correlation analysis showed that Cys C and NT-proBNP were positively correlated with CKD combined with HF(P<0.05).The area under the curve(AUC)values of Cys C and NT-proBNP alone and combined in predicting CKD combined with HF were 0.828,0.868 and 0.904,respectively,and the combined prediction value was the highest.Conclusion:Serum Cys C and NT-proBNP have higher predictive value for CKD combined with HF,and the higher the values,the higher the likelihood of CKD combined with HF.
国家科技期刊平台
NSTL
万方数据
维普
