Effects of Chlamydia Trachomatis and Mycoplasma Genitalia in Genital Tract on Sex Hormones and Inflammatory Factors in Female Infertile Patients
Objective:To investigate the effects of chlamydia trachomatis and mycoplasma genitalia in genital tract on sex hormones and inflammatory factors in female infertile patients.Method:A total of 76 infertile patients admitted to Sanming First Affiliated Hospital of Fujian Medical University from January to December 2022 were selected as the observation group,and 50 healthy subjects were enrolled during the same period as the control group.Both groups were examined for pathogens.Sex hormones,inflammatory factors and anti-endometrial antibodies were examined in the observation group.The positive rate of pathogens was compared between the observation group and the control group.The positive rate of anti-endometrial antibodies,sex hormones and inflammatory factors were compared between infected and uninfected patients in the observation group.Result:The positive rates of chlamydia trachomatis and mycoplasma genitalia in the observation group were 15.79%and 11.84%,respectively,which were significantly higher than 2.00%and 0 in the control group,and the differences were statistically significant(P<0.05).The positive rate of serum anti-endometrial antibody in infected patients was significantly higher than that in uninfected patients,the differences were statistically significant(P<0.05).Follicle-stimulating hormone,luteinizing hormone and estradiol in infected patients were significantly higher than those in uninfected patients,the differences were statistically significant(P<0.05).The levels of interleukin-2 and tumor necrosis factor-α in infected patients were significantly higher than those in uninfected patients,the differences were statistically significant(P<0.05).Conclusion:Infection with chlamydia trachomatis and mycoplasma genitalium in reproductive tract is an important cause of female infertility.Infection with chlamydia trachomatis and mycoplasma genitalium can promote the production of anti-endometrial antibodies and affect the levels of sex hormones and inflammatory factors,thus causing infertility.
国家科技期刊平台
NSTL
万方数据
维普
