首页|急性自发性脑出血患者血清碱性磷酸酶的变化及其临床价值

急性自发性脑出血患者血清碱性磷酸酶的变化及其临床价值

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目的:浅析血清碱性磷酸酶(ALP)在急性自发性脑出血中的疾病诊断、病情评估与短期预后评估价值.方法:回顾性分析 2019 年 1 月—2020 年 12 月深圳市龙华区中心医院 70 例因急性自发性脑出血送院抢救患者的临床资料作为观察1组,将同期于本院接受健康体检的70例健康者的临床资料作为对照1组,比较患者治疗前血清ALP水平与健康者的差异,评价其在急性自发性脑出血中的诊断价值.根据观察1组治疗前格拉斯哥昏迷量表(GCS)评分进行分组,GCS<9分为观察 2 组(n=39),GCS≥9 分为对照 2 组(n=31),对比两组血清ALP水平;观察 1 组均接受相同方案的治疗,比较治疗前后血清ALP水平,评价其对急性自发性脑出血病情的评估价值.对观察 1 组进行为期 6 个月的短期预后随访,统计疾病复发情况,将急性自发性脑出血院外复发者纳入观察 3 组(n=7),将未复发者纳入对照 3 组(n=63),对比两组出院前1 d血清ALP水平,评价其对患者短期预后的评估价值.结果:观察 1 组血清ALP水平高于对照 1 组,差异有统计学意义(P<0.05);观察 2 组血清ALP水平高于对照 2 组,差异有统计学意义(P<0.05);观察 1 组治疗前血清ALP水平高于治疗后,差异有统计学意义(P<0.05);观察3组出院前1 d血清ALP水平高于对照3组,差异有统计学意义(P<0.05).结论:血清ALP水平可用于急性自发性脑出血疾病的诊断、病情评估与短期预后评估,是可应用于疾病各阶段的重要指标,能帮助医方更好地识别病情,进而制定后续准确治疗方案.
Changes and Clinical Value of Serum Alkaline Phosphatase in Patients with Acute Spontaneous Intracerebral Hemorrhage
Objective:To analyze the value of serum alkaline phosphatase(ALP)in disease diagnosis,condition evaluation and short-term prognosis evaluation of acute spontaneous intracerebral hemorrhage.Method:The clinical data of 70 patients with acute spontaneous intracerebral hemorrhage admitted to Shenzhen Longhua District Central Hospital from January 2019 to December 2020 were retrospectively analyzed as observation group 1,and 70 healthy people who received physical examination in our hospital during the same period were used as control group 1,the difference of serum ALP level between patients before treatment and healthy people was compared,and its diagnostic value in acute spontaneous intracerebral hemorrhage was evaluated.According to the Glasgow coma scale(GCS)score of the observation group 1 before treatment,the patients with GCS<9 points was divided into the observation group 2(n=39),and the patients with GCS≥9 points was divided into the control group 2(n=31),the serum ALP level between two groups was compared.The observation group 1 was treated with the same regimen,and the serum ALP level before and after treatment was compared to evaluate its value in evaluating the condition of acute spontaneous cerebral hemorrhage.The observation group 1 was followed up for 6 months for short-term prognosis,and the recurrence of the disease was counted.The patients with recurrence of acute spontaneous cerebral hemorrhage outside the hospital were included in the observation group 3(n=7),and the patients without recurrence were included in the control group 3(n=63).The serum ALP level at 1 d before discharge was compared between two groups to evaluate its value in evaluating the short-term prognosis of patients.Result:The serum ALP level of the observation group 1 was higher than that of the control group 1,and the difference was statistically significant(P<0.05).The serum ALP level of the observation group 2 was higher than that of the control group 2,and the difference was statistically significant(P<0.05).The serum ALP level of the observation group 1 before treatment was higher than that after treatment,and the difference was statistically significant(P<0.05).The serum ALP level of the observation group 3 at 1 d before discharge was higher than that of the control group 3,and the difference was statistically significant(P<0.05).Conclusion:Serum ALP level can be used for the diagnosis,condition evaluation and short-term prognosis of acute spontaneous intracerebral hemorrhage,it is an important index that can be applied to all stages of patients'disease,and can help doctors better identify patients'condition and formulate follow-up accurate treatment plans.

Acute spontaneous intracerebral hemorrhageSerum alkaline phosphataseDiagnosisConditionPrognosisEvaluation

黄文浩、匡文斌、张勇刚、常开源

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深圳市龙华区中心医院 广东 深圳 518110

急性自发性脑出血 血清碱性磷酸酶 诊断 病情 预后 评估

2024

中外医学研究
中国医院管理杂志社

中外医学研究

影响因子:1.149
ISSN:1674-6805
年,卷(期):2024.22(12)
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