Relationship between D-D,Hb,PLR,NLR and Hemorrhagic Transformation after Nonthrombolytic Therapy in Elderly Patients with Acute Cerebral Infarction
Objective:To investigate the relationship between D-dimer(D-D),hemoglobin(Hb),platelets/lymphocytes ratio(PLR),neutrophils/lymphocytes ratio(NLR)and hemorrhagic transformation(HT)in elderly patients with acute cerebral infarction(ACI)after non-thrombolytic therapy.Method:A total of 53 elderly patients with HT after non-thrombolytic therapy of ACI treated in Zunyi City Bozhou District Hospital of Traditional Chinese Medicine from May 2021 to May 2023 were selected as the observation group,and 53 elderly patients without HT after non-thrombolytic therapy of ACI treated in the same period were selected as the control group.The levels of D-D,Hb,PLR and NLR in the observation group and the control group were measured before treatment.Receiver operating characteristic(ROC)curve was drawn to analyze the clinical value of serum D-D,Hb,PLR,NLR alone and combined detection in predicting HT after non-thrombolytic therapy with ACI.After 3 months of follow-up,according to the modified Rankin scale(mRS)score,the patients were divided into good prognosis group(mRS<3 points,n=41)and poor prognosis group(mRS≥3 points,n=12).Serum D-D,Hb,PLR and NLR levels of the good prognosis group and the poor prognosis group were compared.Result:Serum D-D and Hb levels in the observation group were lower than those in the control group,and NLR levels was higher than that in the control group,the differences were statistically significant(P<0.05).ROC curve showed that the area under the curve(AUC)of serum D-D,Hb,NLR alone and combined detection to predict HT occurrence after ACI non-thrombolytic therapy were 0.844,0.807,0.816,0.954,and the combined detection had the highest predictive value.Serum D-D and Hb levels in the poor prognosis group were lower than those in the good prognosis group,and NLR levels was higher than that in the good prognosis group,the differences were statistically significant(P<0.05).Conclusion:The abnormal expression of D-D,Hb and NLR is obvious in elderly ACI non-thrombolytic HT patients.Combined detection can improve the prediction efficiency of HT,and the abnormal expression of these indicators is closely related to the outcome of HT.Clinical attention should be paid to the abnormal expression of these indicators and the monitoring of these indicators should be strengthened.
Acute cerebral infarctionHaemorrhagic transformationD-dimerHemoglobinPlatelet/lymphocytePredictive value
万方数据
维普
