Effect of Xiao'er Chiqiao Qingre Granules on Lung Function,Inflammatory Factors and Th17/Treg in Children with Mycoplasma Pneumonia
Objective:To analyze the effect of Xiao'er Chiqiao Qingre Granules on lung function,inflammatory factors and T helper cell 17(Th17)/regulatory T cell(Treg)in children with mycoplasma pneumonia.Method:A total of 100 children with mycoplasma pneumonia who diagnosed and treated in the Department of Pediatrics of Macheng Second People's Hospital from October 2021 to April 2023 were selected as the research objects,the children were divided into the control group(n=48)and treatment group(n=52)according to different treatment schemes.The control group was treated with routine treatment,and the treatment group was treated with Xiao'er Chiqiao Qingre Granules on the basis of routine treatment.The lung function[forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)],inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],CD4+T lymphocyte subsets(Th17,Treg,Th17/Treg),and related pathway protein expression[phosphatidylinositol 3-kinase(PI3K),protein kinase B(Akt),signal transducer and activator of transcription 3(STAT3)]were compared between the two groups.Result:After treatment,the FEV1,FVC,PEF and Treg in two groups were higher than those before treatment,and the levels of CRP,TNF-α,IL-6,Th17,Th17/Treg and the relative expression of PI3K,Akt and STAT3 mRNA were lower than those before treatment,the FEV1,FVC,PEF and Treg in the treatment group were higher than those in the control group,the levels of CRP,TNF-α,IL-6,Th17,Th17/Treg and the relative expression of PI3K,Akt and STAT3 mRNA in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Xiao'er Chiqiao Qingre Granules can regulate the balance of Th17/Treg cytokines by inhibiting the activation of PI3K,Akt and STAT3 signaling pathways,so as to exert the effect of treating children with mycoplasma pneumonia,it can also improve lung function and reduce the level of inflammatory factors.
Xiao'er Chiqiao Qingre GranulesMycoplasma pneumonia in childrenLung functionInflammatory factors
万方数据
维普
