Effect of Clozapine Combined with Ziprasidone in the Treatment of Patients with Schizophrenia
Objective:To explore the effect of Clozapine combined with Ziprasidone in the treatment of patients with schizophrenia.Method:A total of 80 patients with schizophrenia who treated in the Second People's Hospital of Huangshan City from June 2021 to August 2023 were selected as the research subjects,the patients were divided into the control group and the observation group by random number table method,with 40 patients in each group.The control group received Clozapine combined with Risperidone treatment,while the observation group received Clozapine combined with Ziprasidone treatment.The mental status[brief psychiatric rating scale(BPRS),social dysfunction screening schedule(SDSS),treatment emergent symptom scale(TESS)],renal function indicators,lipid levels,serum levels and glucose metabolism were compared of two groups.Result:There were no significant differences in the SDSS score,blood lipid level,apolipoprotein B(Apo-B)level and glucose metabolism indexes between two groups before treatment(P>0.05);after treatment,the SDSS score,TESS score,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),Apo-B,prealbumin(PA),glycosylated serum protein(GSP)and fasting blood glucose(FBG)in the observation group were lower than those in the control group,and the high density lipoprotein cholesterol(HDL-C)was higher than that in the control group,the differences were statistically significant(P<0.05).There were no significant differences in BPRS score,urea nitrogen(BUN),creatinine(Cr),uric acid(UA),apolipoprotein A1(Apo-A1)and β2-microglobulin(β2-MG)between two groups before and after treatment(P>0.05).Conclusion:In the treatment of patients with schizophrenia,Clozapine combined with Ziprasidone and Clozapine combined with Risperidone show similar efficacy,but Clozapine combined with Ziprasidone can significantly improve the SDSS score and TESS score of patients,optimize blood lipid levels and glucose metabolism indexes,reduce the risk of cardiovascular disease,and have no significant adverse effects on renal function.
万方数据
维普
