Application Effect of Different Doses of Liraglutide Combined with Qishen Yiqi Dropping Pills in Patients with Coronary Heart Disease and T2DM
Objective:To investigate the application effect of different doses of Liraglutide combined with Qishen Yiqi Dropping Pills in patients with coronary heart disease and diabetes mellitus type 2(T2DM).Method:A total of 129 patients with coronary heart disease combined with T2DM admitted to Anping County Hospital of Chinese Medicine from January 2019 to January 2021 were retrospectively selected.According to different treatment plans,the patients were divided into high-dose group(63 cases)and low-dose group(66 cases).The high-dose group was given large-dose Liraglutide combined Qishen Yiqi Dropping Pills,and the low-dose group was given small-dose Liraglutide combined Qishen Yiqi Dropping Pills.Vascular endothelial function,inflammatory factors,cardiac function indexes before and after treatment,adverse events and adverse cardiovascular reactions were compared between the two groups.Result:After treatment,endothelin(ET)and thromboxane B2(TXB2)in the high-dose group were significantly lower than those in the low-dose group,flow-mediated endothelium-dependent vasodilation(FMD)and nondependent vasodilation(NMD)were significantly higher than those in small dose group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and nuclear factor κB(NF-κB)in high-dose group were significantly lower than those in low-dose group,the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(LVEF),cardiac output(CO)and acceleration index(ACI)in high-dose group were higher than those in low-dose group,and the pleural fluid content(TFC)and body vascular resistance(SVR)in high-dose group were lower than those in low-dose group,the differences were statistically significant(P<0.05).There were no significant differences in the incidences of adverse cardiovascular events and adverse reactions between the two groups(P>0.05).Conclusion:Although 1.2 mg/d and 0.6 mg/d Liraglutide combined with Qisen Yiqi Dropping Pills can improve cardiac function,activate endothelial cell activity and reduce inflammation in patients with coronary heart disease and T2DM,the effect of large dose is better.
万方数据
维普
