Objective:To observe the effect of Calcium Dobesilate combined with Aflibercept intravitreal injection in the treatment of patients with diabetic retinopathy.Method:A total of 92 patients with diabetic retinopathy who treated in Suzhou Xiangcheng People's Hospital from June 2019 to March 2022 were selected as the research objects,the patients were divided into the conventional group(46 cases,Aflibercept intravitreal injection)and the study group(46 cases,Calcium Dobesilate combined with Aflibercept intravitreal injection)by random number table method.The best corrected visual acuity(BCVA),macular retinal volume(TMV)and central macular thickness(CMT)in the 5 mm diameter range were compared between two groups before treatment and 1 month,2 months and 3 months after treatment,the clinical efficacy and adverse reactions were compared between two groups.Result:The BCVA and TMV of two groups at 1 month,2 months and 3 months after treatment were better than those before treatment,and the BCVA and TMV at 2 months and 3 months after treatment were better than those at 1 month after treatment,the BCVA of the study group at 1 month,2 months and 3 months after treatment was higher than those of the conventional group,and the TMV were lower than those of the conventional group,the differences were statistically significant(P<0.05).The CMT of two groups at 1 month,2 months and 3 months after treatment were lower than those before treatment,the CMT at 2 months and 3 months after treatment were lower than those at 1 month after treatment,the CMT at 3 months after treatment were lower than those at 2 months after treatment,the CMT of the study group at 1 month,2 months and 3 months after treatment were lower than those of the conventional group,the differences were statistically significant(P<0.05).The total effective rate of the study group was higher than that of the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Calcium Dobesilate combined with Aflibercept intravitreal injection is effective in patients with diabetic retinopathy,which can improve vision and macular edema,and is safe and reliable.
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