首页|曲安奈德联合玻璃酸钠注射治疗膝骨关节炎的效果

曲安奈德联合玻璃酸钠注射治疗膝骨关节炎的效果

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目的:研究曲安奈德联合玻璃酸钠注射治疗膝骨关节炎(KOA)的效果.方法:选取 2020 年 8 月—2023 年8 月厦门医学院附属第二医院收治的 100 例KOA患者作为研究对象,依据随机数表法分为两组,各 50 例.对照组接受玻璃酸钠单药注射治疗,观察组给予曲安奈德联合玻璃酸钠注射治疗,治疗 5 周.比较两组临床疗效、膝关节功能[西安大略和麦克马斯特大学骨关节炎指数(WOMAC)]、骨代谢状况[骨密度(BMD)、骨钙素(OC)]、机体炎症指标[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)]及不良反应发生率.结果:观察组临床总有效率为96.00%,高于对照组的 80.00%,差异有统计学意义(P<0.05).治疗后,观察组疼痛、僵硬、功能障碍评分及总分均低于对照组,差异有统计学意义(P<0.05).治疗后,观察组BMD与OC均高于对照组,差异有统计学意义(P<0.05).治疗后,观察组IL-1、IL-6 及TNF-α均低于对照组,差异有统计学意义(P<0.05).两组不良反应总发生率比较,差异无统计学意义(P>0.05).结论:曲安奈德联合玻璃酸钠注射治疗KOA患者的效果显著,可有效促进机体炎症清除,改善患者的膝关节功能及骨代谢状况,且不增加不良反应发生.
Effect of Triamcinolone Acetonide and Sodium Hyaluronate Injection in the Treatment of Knee Osteoarthritis
Objective:To study the effect of Triamcinolone Acetonide and Sodium Hyaluronate injection in the treatment of knee osteoarthritis(KOA).Method:A total of 100 KOA patients admitted to the Second Affiliated Hospital of Xiamen Medical College from August 2020 to August 2023 were selected as the study objects and divided into two groups according to random number table method,with 50 patients in each group.The control group was treated with Sodium Hyaluronate injection,and the observation group was treated with Triamcinolone Acetonide plus Sodium Hyaluronate injection for 5 weeks.The clinical efficacy,knee function[Western Ontario and McMaster University osteoarthritis index(WOMAC)],bone metabolism[bone mineral density(BMD),osteocalcin(OC)],inflammatory markers[interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]and incidence of adverse reactions were compared between the two groups.Result:The total clinical effective rate of the observation group was 96.00%,which was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of pain,stiffness,dysfunction and total score in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,BMD and OC in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,IL-1,IL-6 and TNF-α in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Triamcinolone Acetonide and Sodium Hyaluronate injection have significant effects in the treatment of KOA patients,which can effectively promote the clearance of inflammation in the body,improve the function of the knee joint and bone metabolism of the patients,and do not increase the occurrence of adverse reactions.

Knee osteoarthritisTriamcinolone AcetonideSodium HyaluronateJoint functionBone metabolism

王竞友、陈韶平、夏天

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厦门医学院附属第二医院 福建 厦门 361021

膝骨关节炎 曲安奈德 玻璃酸钠 关节功能 骨代谢

2024

中外医学研究
中国医院管理杂志社

中外医学研究

影响因子:1.149
ISSN:1674-6805
年,卷(期):2024.22(14)
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