Application of Modified Del Nido and Domestic HTK Cardioplegics in Adult Heart Valve Replacement Surgery
Objective:To analyze effect of modified Del Nido and domestic HTK cardioplegia in adult heart valve replacement surgery.Method:The data of sixty patients with heart valve replacement surgery admitted to the Qinzhou First People's Hospital from January 2022 to July 2023 were retrospectively analyzed.The patients were divided into DN group(30 cases)and HTK group(30 cases)according to the use condition of cardioplegia.HTK group was treated with domestic HTK cardioplegia and DN group was treated with modified Del Nido cardioplegia.Perioperative indexes,postoperative 24 h and 48 h related indexes and renal function were compared between the two groups.Result:The perfusion times of DN group were higher than those in HTK group,the postoperative mechanical ventilation time was longer than that in HTK group,the aortic occlusion time was shorter than that in HTK group,and the automatic relapse rate was higher than that in HTK group,the differences were statistically significant(P<0.05).There was no significant difference in myocardial troponin(cTnI)and creatine kinase isoenzyme(CK-MB)levels between the two groups at 24 h and 48 h after surgery(P>0.05).There was no significant difference in blood urea nitrogen(BUN)and creatinine(Scr)levels between the two groups at 24 h and 48 h after surgery(P>0.05).Conclusion:Compared with domestic HTK cardioplegia,the modified Del Nido cardioplegia used in adult heart valve replacement surgery can shorten the time of aortic occlusion,increase the automatic relapse rate,the number of perfusion is many and postoperative mechanical ventilation time is long,but both of them have good myocardial protection function.
Heart valveValve replacement surgeryModified Del Nido cardioplegiaDomestic HTK cardioplegia solution