Effect of High-flow Nasal Cannula Oxygen Therapy on Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Respiratory Acidosis
Objective:To analyze the effect of high-flow nasal cannula oxygen therapy instrument on acute exacerbation of chronic obstructive pulmonary disease with respiratory acidosis,and to explore its influence on blood gas index and lung function.Method:The clinical data of 100 patients with acute exacerbation of chronic obstructive pulmonary disease with respiratory acidosis treated in the Department of Respiratory and Critical Care in Beijing Changping Hospital from January 2022 to October 2023 were retrospectively analyzed.They were divided into two groups according to different treatment methods,with 50 cases in each group.The observation group received high-flow nasal cannula oxygen therapy,and the control group received non-invasive positive pressure ventilation.Blood gas index,lung function index,therapeutic effect and occurrence of adverse reactions between the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in blood gas index and lung function index between the two groups(P>0.05).After treatment,pH value,oxygen partial pressure(PaO2)and oxygenation index(OI)of the two groups were higher than those before treatment,and partial pressure of carbon dioxide(PaCO2)was lower than that before treatment,and pH value,PaO2 and OI of the observation group were higher than those of the control group,and PaCO2 was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the first second forced expiratory volume(FEV1),forced vital capacity(FVC),peak expiratory flow rate(PEF),and the first second forced expiratory volume/forced vital capacity(FEV1/FVC%)in both groups were higher than those before treatment,and which in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:High-flow nasal cannula oxygen therapy and non-invasive positive pressure ventilation are both effective methods for assisted ventilation of patients with acute exacerbation of chronic obstructive pulmonary disease with respiratory acidosis,and high-flow nasal cannula oxygen therapy can effectively improve the therapeutic effect,improve the blood gas index and lung function of patients,with fewer adverse reactions and higher safety.
Acute exacerbation of chronic obstructive pulmonary disease with respiratory acidosisHigh-flow nasal cannula oxygen therapyNon-invasive positive pressure ventilationBlood gas indexLung function
万方数据
维普
