Comparison of Efficacy and Safety of Different Ratios of Piperacillin/Tazobactam in the Treatment of AECOPD Complicated with Pseudomonas Aeruginosa Infection
Objective:To explore and compare the efficacy and safety of different ratios of Piperacillin/Tazobactam in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with Pseudomonas aeruginosa infection.Method:A total of 60 AECOPD patients complicated with Pseudomonas aeruginosa infection who treated in Yinjiang County People's Hospital from August 2019 to August 2023 were selected as the study objects,and they were divided into the low ratio group(n=30)and the high ratio group(n=30)based on different drug ratios.The low ratio group was given Piperacillin/Tazobactam at a ratio of 4∶1,while the high ratio group was given Piperacillin/Tazobactam at a ratio of 8∶1,two groups were treated continuously for 1 week.The inflammatory indexes,lung function and disease severity before and after treatment were compared between two groups,the clinical efficacy was evaluated after treatment,and the occurrence of adverse reactions during treatment was recorded.Result:After treatment,the white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT),acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)and modified British Medical Research Council dyspnea index(mMRC)in two groups were decreased,and the differences were statistically significant(P<0.05),those in the low ratio group were slightly lower than those in the high ratio group,but the differences were not statistically significant(P>0.05).After treatment,the forced expiratory volume in the one second(FEV1),forced vital capacity(FVC),and one-second rate(FEV1/FVC%)of two groups increased,and the differences were statistically significant(P<0.05),those in the low ratio group were slightly lower than those in the high ratio group,but the differences were not statistically significant(P>0.05).The total effective rate in the low ratio group was 86.67%,which was slightly higher than 73.33%in the control group,but the difference was not statistically significant(P>0.05).The incidence of adverse reactions in the low ratio group was 30.00%,which was higher than 10.00%in the high ratio group,the difference was statistically significant(P<0.05).Conclusion:The treatment of AECOPD patients complicated with Pseudomonas aeruginosa infection by Piperacillin/Tazobactam at a ratio of 4∶1 and 8∶1 has similar effects,but 8∶1 ratio of Piperacillin/Tazobactam can reduce the incidence of adverse reactions.
Piperacillin/TazobactamAcute exacerbation of chronic obstructive pulmonary diseasePseudomonas aeruginosa infectionClinical efficacySafety
万方数据
维普
