Effects of Recombinant Human Growth Hormone Combined with Leuprorelin Acetate for Injection on Growth and Development of Children with Idiopathic Central Precocious Puberty
Objective:To explore the effects of Recombinant Human Growth Hormone(rhGH)combined with Leuprorelin Acetate for Injection on the growth and development of children with idiopathic central precocious puberty(ICPP).Method:A total of 86 ICPP children treated in Putian Maternal and Child Health Hospital from January 2021 to August 2022 were selected as the study objects.According to the method of random number table,the patients were divided into two groups,with 43 cases in each group.The control group was treated with Leuprorelin Acetate for Injection,the observation group was treated with rhGH on the basis of the control group.The clinical effects,sex hormone levels,growth indexes,uterine and ovarian volumes and occurrence of adverse reactions were compared between the two groups.Result:After 12 months of treatment,the levels of luteinizing hormone(LH),estradiol(E2)and follicle stimulating hormone(FSH)in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 12 months of treatment,the bone age difference value(∆BA)in two groups were lower than those before treatment,annual growth rate,height of bone age standard deviation score(HtSDS-BA),body mass index(BMI),predicted adult height(PAH)were higher than those before treatment,while the ∆BA in the observation group was lower than that in the control group,the annual growth rate,HtSDS-BA and PAH in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After 12 months of treatment,the volume of uterus and ovary in two groups were smaller than those before treatment,and those in the observation group were significantly smaller than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion:rhGH combined with Leuprelin Acetate for Injection has a good effect in the treatment of ICPP children,which is beneficial to improve the level of sex hormones in children,delay the bone maturation process,regulate the growth index of children,improve the volume of uterus and ovary,and has high safety.
Idiopathic central precocious pubertyRecombinant Human Growth HormoneLeuprelin AcetateSex hormone
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