Effect of Levofloxacin Hydrochloride Ear Drops Combined with Dexamethasone in the Treatment of Acute Suppurative Otitis Media
Objective:To observe the effect of Levofloxacin Hydrochloride Ear Drops combined with Dexamethasone in the treatment of acute suppurative otitis media(ASOM).Method:A total of 100 patients with ASOM admitted to the Second People's Hospital of Jiuquan City from May 2019 to May 2023 were selected.According to the random envelope method,they were divided into control group and experimental group,with 50 cases in each group.The control group was given Levofloxacin Hydrochloride Ear Drops,and the experimental group was given Levofloxacin Hydrochloride Ear Drops combined with Dexamethasone.The clinical efficacy,inflammatory factors,hearing threshold before and after treatment,symptom resolution time and adverse reactions of the two groups were compared.Result:The total effective rate of experimental group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,the level of interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hearing threshold in both groups decreased,the levels of TNF-α,IL-6,IL-8 and hearing threshold in experimental group were lower than those in control group,and the differences were statistically significant(P<0.05).The regression time of ear pain,pus discharge,ear blockage,fever in experimental group were earlier than those in control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Levofloxacin Hydrochloride Ear Drops combined with Dexamethasone in the treatment of APOM patients can further improve the efficacy,promote the regression of symptoms,improve inflammatory reaction and hearing sensitivity,and have good safety.
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