Mechanism of Nitric Oxide Involved in the Occurrence of Epilepsy
Epilepsy is a chronic brain disease caused by abnormal discharge of brain neurons,which is characterized by recurrent,episodic and transient central nervous system dysfunction,which can not only induce migraines,anxiety disorders and other diseases,but also lead to psychological and social dysfunction in patients,seriously affecting the physical and mental health of patients.The pathogenic factors of epilepsy are many and complex,but its pathogenic mechanism has not been fully clarified,which may be related to abnormal discharge of brain neurons and abnormal activity of cerebral cortex.The treatment period of epilepsy is long and difficult,and the effect is not good for drug-resistant epilepsy and generalized tonic epilepsy.Nitric oxide(NO),as a diatomic gas,widely exists in the human body and can be involved in regulating the basic activities of the human body.NO is obviously correlated with epilepsy and has a bidirectional regulatory effect,so NO can be used to treat epilepsy,but adverse reactions may occur in the treatment process,and its clinical effect needs to be further optimized.This article reviewed the relationship between NO and the pathogenesis of epilepsy in order to provide new ideas for clinical diagnosis and treatment.
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