Influence of Probiotics for Disease Control and Th1,Th2 of Children with Bronchial Asthma
Objective:To investigate the influence of probiotics for disease control and Th1,Th2 of children with bronchial asthma.Method:A total of 80 children with bronchial asthma admitted to Sanming Integrated Traditional Chinese and Western Medicine Hospital from May 2021 to February 2023 were selected and divided into two groups according to random number table method,with 40 cases in each group.The control group received routine bronchial asthma treatment,and the observation group received probiotics on the basis of the control group.The total effective rate of asthma control,symptom and sign disappearance time,quality of life[quality of life scale for children with asthma(PAQLQ scale)],Th1 cytokines[interferon γ(IFN-γ)and interleukin-2(IL-2)]and Th2 cytokines[interleukin-4(IL-4)and interleukin-5(IL-5)and interleukin-6(IL-6)]were compared between the two groups.Result:The total effective rate of asthma control in the observation group was significantly higher than that in the control group,and the disappearance time of symptoms and signs were significantly shorter than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in PAQLQ scale scores,Th1 cytokines and Th2 cytokines between the two groups before treatment(P>0.05).After 2 weeks and 4 weeks of treatment,PAQLQ scale scores and Th1 cytokines in the two groups were significantly higher than those before treatment,and those in the observation group were higher than those in the control group,and Th2 cytokines were significantly lower than those before treatment,the those in observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The probiotics can effectively improve the disease state of children with bronchial asthma,and its improvement for Th1,Th2 imbalance is better.
国家科技期刊平台
NSTL
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