Effect of Continuous Renal Replacement Therapy in the Treatment of Patients with Sepsis and Acute Kidney Injury
Objective:To explore the effect of continuous renal replacement therapy(CRRT)in the treatment of patients with sepsis and acute kidney injury.Method:A total of 80 patients with sepsis and acute kidney injury admitted to the Intensive Care Department of Zhangzhou Traditional Chinese Medicine Hospital from January 2021 to June 2023 were retrospectively selected.They were divided into CRRT group(40 cases)and intermittent hemodialysis(IHD)group(40 cases)according to different treatment methods.The CRRT group was given CRRT and the IHD group was given IHD.Renal function,renal hemodynamics,inflammatory factors and condition were compared between the two groups before treatment and after 1 week of treatment.Result:After 1 week of treatment,serum creatinine(Scr)and blood urea nitrogen(BUN)were decreased and albumin(ALB)were increased in both groups,Scr and BUN levels in CRRT group were lower than those in IHD group,the differences were statistically significant(P<0.05).After 1 week of treatment,the peak intensity(PI),mean transit time(MTT)and area under the curve(AUC)of the two groups were increased,and the PI,MTT and AUC of the CRRT group were higher than those of the IHD group,the differences were statistically significant(P<0.05).After 1 week of treatment,C-reactive protein(CRP),pocalcitonin(PCT)and white blood cell(WBC)count decreased in both groups,while CRP,PCT and WBC in CRRT group were lower than those in IHD group,the differences were statistically significant(P<0.05).After 1 week of treatment,the acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)scores of both groups were decreased,and the APACHE Ⅱ scores of the CRRT group were lower than those of the IHD group,the differences were statistically significant(P<0.05).Conclusion:CRRT is better in improving renal function,renal hemodynamics and inflammatory response in the treatment of sepsis with acute renal injury.
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