Analysis of the Expression Levels of TGF-β1 and ZEB2 in Epithelial Ovarian Cancer Tissue and Their Relationship with Clinical Pathological Features and Prognosis
Objective:To analyze the expression of transforming growth factor β1(TGF-β1)and E-box binding zinc finger protein 2(ZEB2)in epithelial ovarian cancer tissue and their relationship with clinical pathological features and prognosis.Method:A total of 30 tissue paraffin specimens of epithelial ovarian cancer patients diagnosed and treated in the Gynecology Department of the Second Affiliated Hospital of University of South China from January 2020 to December 2021 were included in the experimental group,and 30 tissue paraffin specimens of benign ovarian epithelial tumors patients collected in the Gynecology Department of our hospital during the same period were included in the control group.The expression levels of TGF-β1 and ZEB2 in the two groups were detected by SP immunohistochemistry,and the positive expression rates were compared.The positive expression rates of TGF-β1 and ZEB2 in tissue paraffin specimens of epithelial ovarian cancer patients with different ages,pathological types,disease stages and tissue differentiation were analyzed.The experimental group was followed up for 1 year,the prognosis was analyzed,and the positive expression rates of TGF-β1 and ZEB2 in tissue paraffin specimens of surviving patients and dead patients were compared.logistic regression analysis was used to analyze the correlation between positive expression of TGF-β1 and ZEB2 and prognosis of patients with epithelial ovarian cancer.Result:The positive expression rates of TGF-β1 and ZEB2 in experimental group were higher than those in control group,and the differences were statistically significant(P<0.05).There were no significant differences in the positive expression rates of TGF-β1 and ZEB2 in tissue paraffin specimens of epithelial ovarian cancer patients of different ages and pathological types(P>0.05).The positive expression rates of TGF-β1 and ZEB2 in tissue paraffin specimens of epithelial ovarian cancer patients with different disease stages and tissue differentiation were compared,and the differences were statistically significant(P<0.05).After 1 year of follow-up,16 patients survived and 14 died.The positive expression rates of TGF-β1 and ZEB2 in tissue paraffin specimens of surviving patients in experimental group were lower than those of dead patients,and the differences were statistically significant(P<0.05).logistic analysis showed that the positive expression of TGF-β1 and ZEB2 were risk factors for the prognosis of epithelial ovarian cancer patients.Conclusion:TGF-β1 and ZEB2 were highly expressed in epithelial ovarian cancer tissues,and their positive expression rates were significantly correlated with disease stage and tissue differentiation degree.The positive expression of TGF-β1 and ZEB2 are independent risk factors for the prognosis of patients with epithelial ovarian cancer.
国家科技期刊平台
NSTL
万方数据
