Effect of Budesonide Combined with Montelukast Sodium in the Treatment of Elderly Patients with Exacerbation of Chronic Obstructive Emphysema
Objective:To explore the effect of Budesonide combined with Montelukast Sodium in the treatment of elderly patients with exacerbation of chronic obstructive emphysema.Method:A total of 121 elderly patients with exacerbation of chronic obstructive emphysema who treated in Jianli People's Hospital from November 2020 to October 2023 were selected as the study objects,and they were divided into the control group(n=60)and the experimental group(n=61)according to different treatment methods.The control group was given conventional treatment combined with Budesonide aerosol inhalation,and the experimental group was given Montelukast Sodium therapy on the basis of the control group.The clinical efficacy,pulmonary ventilation function,inflammatory factors and quality of life of two groups were compared,and the safety was evaluated.Result:The total effective rate of the experimental group was 95.08%,which was higher than 83.33%of the control group,the difference was statistically significant(P<0.05).After 1 week of treatment,the specific airway conductivity,forced vital capacity(FVC)and peak expiratory flow rate(PEF)in two groups were higher than those before treatment,and the airway resistance were lower than those before treatment,and the airway conductivity,PEF and FVC in the experimental group were higher than those in the control group,and the airway resistance was lower than that in the control group,the differences were statistically significant(P<0.05).After 1 week of treatment,the C-reactive protein(CRP),white blood cell(WBC)count,eosinophilic count and erythrocyte sedimentation rate(ESR)in two groups were lower than those before treatment,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).After 1 week of treatment,the scores of St.George's Hospital respiratory problems questionnaire(SGRQ)in two groups were lower than those before treatment,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion:Budesonide combined with Montelukast Sodium can inhibit the release of inflammatory factors in elderly patients with exacerbation of chronic obstructive emphysema,improve lung ventilation function,promote clinical efficacy and quality of life,and is safe.
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