Effect of Tirofiban Sodium Chloride Injection Combined with Interventional Therapy in Patients with Acute Cerebral Infarction
Objective:To investigate the clinical effect Tirofiban Sodium Chloride Injection combined with interventional therapy in patients with acute cerebral infarction.Method:A total of 180 patients with acute cerebral infarction who admitted to General Hospital of the Yangtze River Shipping from July 2021 to June 2023 were selected as the study subjects,they were divided into the experimental group(n=90)and the control group(n=90)by random number table method.The control group was given interventional therapy,and the experimental group was treated with Tirofiban Sodium Chloride Injection on the basis of the control group.The therapeutic effect,neurological deficit[National Institute of Health stroke scale(NIHSS)],coagulation function indexes and adverse events were compared between two groups.Result:The total effective rate of the experimental group was 95.56%,which was significantly higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in NIHSS score between two groups(P>0.05);after treatment,the NIHSS scores of two groups were lower than those before treatment,and that in the experimental group was lower than that in the control group,the differences were statistically significant(P<0.05).The incidence of adverse events in the experimental group was 22.22%,compared with 33.33%in the control group,the difference was not statistically significant(P>0.05).Before treatment,there were no significant differences in the coagulation function indexes between two groups(P>0.05);after treatment,the thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)of two groups were longer than those before treatment,and those in the experimental group were longer than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Tirofiban Sodium Chloride Injection combined with interventional therapy in patients with acute cerebral infarction has a significant effect,which can improve coagulation function,reduce nerve function damage,and will not increase the incidence of adverse events.
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