Efficacy of Vaginal Lavage No.1 Formula Combined with Lactobacillus on Persistent HR-HPV Infection of Cervix
Objective:To investigate the clinical efficacy of Vaginal Lavage No.1 Formula combined with Lactobacillus in the treatment of persistent cervical high-risk human papillomavirus(HR-HPV)infection and effect of vaginal microecology.Method:A total of 119 patients with persistent cervical HR-HPV infection admitted to the Gynecological Clinic of the Sixth Affiliated Hospital of Jinan University from March 2021 to March 2023 were selected as the study objects.They were randomly divided into three groups;the study group(n=44)was treated with Vaginal Lavage No.1 Formula combined with Live Lactobacillus Capsules for Vaginal Use,and the interferon group(n=41)was treated with Human Interferon α2b Vaginal Effervescent Tablets;the blank group(n=34)refused medication.The negative conversion rate of HR-HPV and the cytological changes of cervix in the three groups were observed,and the vaginal microecology of the three groups was analyzed.Result:The negative conversion rate of HR-HPV in the study group was 75.61%,which were higher than 52.63%,14.71%in the interferon group and the blank group,and the differences were statistically significant(P<0.05).After treatment,the cytological upgrade rate of the study group was 2.44%,which was lower than 32.35%of the blank group,the difference was statistically significant(P<0.05);the cytological degradation rate of the study group was 43.90%,which were higher than 21.05%and 5.88%of the interferon group and the blank group,the differences were statistically significant(P<0.05).After treatment,the negative proportion of hydrogen peroxide(H2O2)and leucocyte esterase(LE)in study group were higher than those in interferon group and blank group,and the negative proportion of β-glucuronidase(GUS)and coagulase(GADP)were higher than those in blank group,the differences were statistically significant(P<0.05).Conclusion:Vaginal Lavage No.1 Formula combined with Lactobacillus can effectively clear cervical HR-HPV infection,improve vaginal microecological environment,and inhibit cervical histological escalation.
High-risk human papillomavirusPersistent infectionVaginal Lavage No.1 FormulaLactobacillus
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