Clinical Effect of Modified Zhishi Xiebai Guizhi Decoction in the Treatment of Acute Myocardial Infarction with Phlegm Turbid Blockage Symptom
Objective:To observe the clinical effect of Modified Zhishi Xiebai Guizhi Decoction in the treatment of acute myocardial infarction with phlegm turbid blockage symptom.Method:A total of 96 patients with acute myocardial infarction with phlegm turbid blockage symptom treated in Yan'an People's Hospital from January 2022 to September 2023 were selected.They were divided into control group(n=48)and observation group(n=48)according to random number table method.The control group was given conventional western medicine treatment,and the observation group was given Modified Zhishi Xiebai Guizhi Decoction on the basis of control group.The clinical efficacy,traditional Chinese medicine syndrome score,heart function,markers of myocardial injury,inflammatory factors before and after treatment and adverse reactions of the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of chest pain,shortness of breath,full chest cavity tightness,palpitation in both groups were decreased,and the scores of chest pain,shortness of breath,full chest cavity tightness,palpitation in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,stroke output(SV),left ventricular ejection fraction(LVEF)and cardiac output(CO)in both groups were increased,and SV,LVEF and CO in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).After treatment,the levels of myoglobin(MYO),hypersensitive troponin T(hs-TnT)and creatine kinase isoenzyme(CK-MB)in both groups were decreased,and the levels of MYO,hs-TnT and CK-MB in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were decreased in both groups,while the levels of interleukin-10(IL-10)were increased,the levels of IL-6 and TNF-α in observation group were lower than those in control group,and the levels of IL-10 were higher than those in control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Zhishi Xiebai Guizhi Decoction can further reduce myocardial injury in patients with acute myocardial infarction,improve cardiac function,enhance clinical efficacy,alleviate clinical symptoms,down-regulate the expression of inflammatory factors,and have good safety.
万方数据
维普
