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丙戊酸钠联合脑电生物反馈治疗双相情感障碍的效果

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目的:探究丙戊酸钠联合脑电生物反馈治疗双相情感障碍(BPD)的效果.方法:选择 2021 年 8 月—2023 年8 月在北京市海淀区心理康复医院治疗的 80 例BPD患者作为研究对象,应用随机数表法将其分为对照组(给予丙戊酸钠治疗)及研究组(给予丙戊酸钠联合脑电生物反馈治疗),各 40 例.比较两组临床疗效、Bech-Rafaelsen躁狂量表(BRMS)评分、临床总体印象疾病严重度量表-双相障碍版(CGI-s-BP)评分、阳性和阴性综合征量表(PANSS)评分、修改版外显攻击行为量表(MOAS)评分、汉密尔顿抑郁量表(HAMD)评分、不良反应量表(TESS)评分、炎症因子[白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、巨噬细胞移动抑制因子(MIF)]、细胞因子[同型半胱氨酸(Hcy)、星形胶质源性蛋白(S100β)、5-羟色胺(5-HT)]水平.结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05).治疗后,两组BRMS评分、CGI-s-BP评分、PANSS评分、MOAS评分、HAMD评分、IL-6、IL-1β、MIF、S100β、Hcy均低于治疗前,5-HT高于治疗前,且研究组BRMS评分、CGI-s-BP评分、PANSS评分、MOAS评分、HAMD评分、IL-6、IL-1β、MIF、S100β、Hcy低于对照组,5-HT高于对照组,差异有统计学意义(P<0.05);两组TESS评分比较,差异无统计学意义(P>0.05).结论:BPD患者接受丙戊酸钠联合脑电生物反馈治疗,可改善患者精神症状,降低炎症水平,调节 5-HT、Hcy、S100β,安全性较高.
Effect of Sodium Valproate Combined with EEG biofeedback in the treatment of Bipolar Disorder
Objective:To explore the effect of Sodium Valproate combined with EEG biofeedback in the treatment of bipolar disorder(BPD).Method:A total of 80 BPD patients treated in the Beijing Haidian District Mental Rehabilitation Hospital from August 2021 to August 2023 were selected as the study objects,and they were divided into the control group(receiving Sodium Valproate treatment)and the study group(receiving Sodium Valproate combined with EEG biofeedback treatment)by random number table method,with 40 cases in each group.Clinical efficacy,Bech-Rafaelsen mania scale(BRMS)score,clinical global impressions scale-bipolar disorder(CGI-s-BP)score,positive and negative syndrome scale(PANSS)score,modified overt aggression scale(MOAS)score,Hamilton depression scale(HAMD)score,treatment emergent symptom scale(TESS)score,levels of inflammatory factors[interleukin-6(IL-6),interleukin-1β(IL-1β),macrophage migration inhibitor factor(MIF)],cytokines[homocysteine(Hcy),astroglia-derived protein(S100β),5-hydroxytryptamine(5-HT)]were compared between the two groups.Result:The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,BRMS score,CGI-s-BP score,PANSS score,MOAS score,HAMD score,IL-6,IL-1β,MIF,S100β and Hcy in both groups were lower than those before treatment,and 5-HT was higher than that before treatment,and BRMS score,CGI-s-BP score,PANSS score,MOAS score,HAMD score,IL-6,IL-1β,MIF,S100β and Hcy in the study group were lower than those in the control group,and 5-HT was higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in TESS scores between the two groups(P>0.05).Conclusion:Patients with BPD receiving Sodium Valproate combined with EEG biofeedback can improve mental symptoms,reduce inflammation,regulate 5-HT,Hcy,S100β,and have high safety.

Sodium ValproateEEG biofeedbackBipolar disorderOxidative stressInflammatory factors

杨娜、肖雪、何锐

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北京市海淀区心理康复医院 北京 100194

丙戊酸钠 脑电生物反馈 双相情感障碍 氧化应激 炎症因子

2024

中外医学研究
中国医院管理杂志社

中外医学研究

影响因子:1.149
ISSN:1674-6805
年,卷(期):2024.22(19)