Effect of Remifentanil Combined with Sufentanil on Patients Undergoing Endoscopic Submucosal Dissection
Objective:To investigate the effect of Remifentanil combined with Sufentanil on patients undergoing endoscopic submucosal dissection.Method:A total of 80 patients with endoscopic submucosal dissection admitted to the First Affiliated Hospital of Bengbu Medical University from June 2022 to June 2023 were selected.They were randomly divided into control group and observation group,40 cases in each group.Both groups were given endoscopic submucosal dissection,the control group was given Remifentanil anesthesia induction,and the observation group was given Remifentanil combined with Sufentanil anesthesia induction.Heart rate(HR),mean arterial pressure(MAP)before anesthesia begins,after anesthesia induction is completed,at the beginning of operation,and at the end of operation,stress index at the beginning and end of operation,sedation effect and adverse reactions were compared between the two groups.Result:After anesthesia induction is completed,at the beginning of operation and at the end of operation,HR and MAP levels in both groups were decreased,and HR and MAP levels in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).At the end of the operation,the levels of epinephrine(E)and norepinephrine(NE)in both groups were increased,and the levels of E and NE in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The extubation time and eye opening time of the observation group were shorter than that of the control group,and the agitation score was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the adverse reactions of postoperative complications between the two groups(P>0.05).Conclusion:Remifentanil combined with Sufentanil is well applied in endoscopic submucosal dissection,which can effectively stabilize intraoperative hemodynamics of patients,promote patients to wake up as soon as possible,and alleviate patients'post-operative stress and agitation after awakening.
万方数据
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