Changes of Serum HIF-1α and β2-MG Levels in Patients with Primary Myelodysplastic Syndrome and Their Clinical Significance
Objective:To explore the changes of serum hypoxia inducible factor-1α(HIF-1α)and β2-microglobulin(β2-MG)levels in patients with primary myelodysplastic syndrome(MDS)and their clinical significance.Method:A total of 80 patients with primary MDS admitted to Beijing Huairou Hospital from September 2020 to August 2023 were selected as the case group,and another 80 healthy physical examination personnel during the same period were selected as the control group.The levels of HIF-1α and β2-MG in two groups were detected.Relevant treatment was performed in the case group.General data of patients in the case group were collected.The levels of HIF-1α and β2-MG in two groups,and patients with different MDS international prognostic scoring system(IPSS)grades in case groups were compared.The correlation between HIF-1α,β2-MG levels and IPSS grading was analyzed.The therapeutic effect of case group was analyzed,and the therapeutic effect of patients with primary MDS was analyzed by univariate and multifactorial analysis.Result:Serum HIF-1α and β2-MG levels in case group were higher than those in control group,and the differences were statistically significant(P<0.05).The levels of HIF-1α and β2-MG in high-risk patients were higher than those in low-risk patients and medium-risk patients,and the levels of HIF-1α and β2-MG in medium-risk patients were higher than those in low-risk patients,the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum HIF-1α and β2-MG levels were positively correlated with IPSS grade(r=0.628,0.594,P<0.05).After treatment,among the 80 patients with primary MDS,36 had complete remission,accounting for 45.00%(36/80),21 had partial remission,accounting for 26.25%(21/80),and 23 had no remission,accounting for 28.75%(23/80).Serum HIF-1α and β2-MG levels in patients with no remission were higher than those in patients with remission,and the differences were statistically significant(P<0.05).Multivariate logistic analysis showed that serum HIF-1α and β2-MG were independent risk factors affecting the therapeutic effect of patients with primary MDS(P<0.05).Conclusion:Serum HIF-1α and β2-MG are highly expressed in patients with primary MDS,and their levels increase further with the increase of IPSS grade,which can be used as an important indicator to evaluate the treatment effect of patients.
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