Application Effects of Polidocanol Combined with Intravascular Laser in Patients with Lower Limb Varicose Veins
Objective:To investigate the effect of Polidocanol combined with intracavitary laser in the treatment of lower limb varicose veins.Method:A total of 96 patients with lower limb varicose veins treated in the Second Hospital of Longyan from January 2022 to December 2023 were selected as the study objects and randomly divided into control group and observation group,with 48 cases in each group.The control group was treated with high ligation and fractional exfoliation of the saphenous vein,and the observation group was treated with intracavitary laser closure and Polidocanol.Blood coagulation function index,venous clinical severity score(VCSS),stress function index,vascular endothelial function index and complications were compared between the two groups.Result:Before treatment,there were no significant differences in coagulation function index,VCSS score,stress function index and vascular endothelial function index between the two groups(P>0.05).After treatment,plasma fibrinogen(FIB),plasminogen activator inhibitor-1(PAI-1),VCSS,superoxide dismutase(SOD),serum endothelin-1(ET-1)and peripheral blood circulating endothelial cells(CEC)in both groups were lower than those before treatment,the levels of plasminogenase activator(t-PA),serum malondialdehyde(MDA)and nitric oxide(NO)were higher than those before treatment,and the levels of FIB,PAI-1,VCSS,MDA,ET-1 and CEC in observation group were lower than those in control group,while the levels of t-PA,SOD and NO were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,the total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:For patients with lower limb varicose veins,treatment with Polidocanol combined with intracavitary laser can effectively relieve symptoms,improve coagulation function,and reduce the incidence of complications.
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