Effect of Salbutamol and Budesonide in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Objective:To investigate the effect of Salbutamol and Budesonide in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:A total of 106 AECOPD patients admitted to Bijie Hospital of Traditional Chinese Medicine from April 2022 to April 2023 were selected as the study objects,and they were divided into two groups according to the random number table method,with 53 cases in each group.Both groups received basic treatment such as anti-infection and routine oxygen inhalation.The control group was treated with Budesonide suspension,and the observation group received Albuterol based on the control group.The treatment effect,inflammatory factor level,blood gas analysis index,lung function index and the occurrence of adverse reactions between the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin(IL)-6,IL-8 and IL-10 in the two groups were lower than before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the arterial partial pressure of carbon dioxide(PaCO2)in both groups were lower than that before treatment,and that in the observation group was lower than that in the control group,the arterial oxygen saturation(SaO2)and arterial partial pressure of oxygen(PaO2)were higher than those before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and FEV1/FVC%in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of dizziness,rash,arrhythmia,nausea and vomiting between the two groups(P>0.05).Conclusion:Salbutamol combined with Budesonide has a good clinical effect,plays a restraining effect on inflammatory response,which is conducive to improve the blood gas analysis of patients,promote the recovery of lung function,and has high safety.
Chronic obstructive pulmonary diseaseAcute exacerbationSalbutamolBudesonideInflammatory responseBlood gas analysis
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