Role of Rivaroxaban in the Prevention of Catheter Related Thrombosis
Objective:Effect of Rivaroxaban and Low Molecular Weight Heparin on prevention of catheter related thrombosis(CRT)in intensive care unit(ICU)patients.Method:A total of 120 patients in the ICU of Baotou Central Hospital from June 2019 to September 2021 who met the admission criteria for central venous catheterization were selected as the study objects,and divided into Rivaroxaban group,Low Molecular Weight Heparin group and blank control group according to the random number table method,with 40 cases in each group.After deep venous puncture catheterization,all three groups were given routine care with deep venous catheterization,they were give Rivaroxaban,Low Molecular Weight Heparin and non-anticoagulant treatment,respectively.The incidence of CRT,coagulation indexes[plasma fibrinogen(FIB),D-dimer(D-D)]at different time points and the occurrence of anticoagulant drug-related bleeding were compared among the three groups.Result:The incidence of CRT in blank control group was significantly higher than that in Rivaroxaban group and Low Molecular Weight Heparin group,the differences were statistically significant(P<0.05),but there was no statistical significance in the incidence of CRT between Rivaroxaban group and Low Molecular Weight Heparin group(P>0.05).At T2,T3 and T4,FIB and D-D in Rivaroxaban group and Low Molecular Weight Heparin group were lower than that at T1;at T3 and T4,FIB and D-D in Rivaroxaban group and Low Molecular Weight Heparin group were lower than that at T2;at T4,FIB and D-D in Rivaroxaban group and Low Molecular Weight Heparin group were lower than that T3,and the differences were statistically significant(P<0.05).At T2,T3 and T4,FIB and D-D in Rivaroxaban group were lower than those in Low Molecular Weight Heparin group and blank control group,and which in Low Molecular Weight Heparin group was lower than those in blank control group,the differences were statistically significant(P<0.05).The difference of FIB and D-D among the three groups at different time points were statistically significant(P<0.001);the difference of FIB and D-D among the three groups were statistically significant(P<0.001);there was interaction between groups and time(P<0.001).The total incidence of bleeding associated with Low Molecular Weight Heparin group was higher than that of Rivaroxaban group,and the difference was statistically significant(P<0.05).Conclusion:In the prevention of CRT in ICU patients,both Rivaroxaban and Low Molecular Weight Heparin are effective,but Rivaroxaban has better effect on the improvement of coagulation function and higher safety.
Catheter related thrombosisRivaroxabanIntensive care unitPlasma fibrinogenD-dimer
万方数据
维普
