Application Effect of Pemetrexed Combined with Intensity Modulated Radiotherapy Technique in the Treatment of Stage Ⅲ Non-small Cell Lung Cancer
Objective:To explore the application effect of Pemetrexed combined with Intensity modulated radiotherapy technique(IMRt)in the treatment of stage Ⅲ non-small cell lung cancer(NSCLC).Method:A total of 68 patients with stage Ⅲ non-small cell lung cancer were randomly admitted to the Department of Oncology of Zhongxiang People's Hospital from January 2021 to August 2022 were selected.The patients were divided into two groups by random number table method,34 cases in each group.The Pemetrexed group was treated with Pemetrexed combined with IMRt,while the Docetaxel group was treated with Docetaxel combined with IMRt.The clinical efficacy,survival rate,and adverse reactions between the two groups were compared between the two groups.Result:After 4 cycles of treatment,there were no significant differences in objective remission rate and clinical control rate between Pemetrexed group and Docetaxel group(P>0.05).The incidences of leukopenia,nausea/vomiting,and hair loss in the Pemetrexed group were significantly lower than those in the Docetaxel group,and the differences were statistically significant(P<0.05).There were no significant differences in disease progression and the 1 year survival rate between the two groups(P>0.05).Conclusion:The efficacy of Pemetrexed chemotherapy combined with IMRt and Docetaxel with IMRt in the treatment of stage Ⅲ NSCLC is comparable.However,the incidence of adverse reactions with Pemetrexed is low,which deserves clinical attention.
万方数据
维普
