Effect of Moluodan Combined with Quadruple Therapy in the Treatment of Helicobacter Pylori-related Chronic Atrophic Gastritis
Objective:To explore the effect of Moluodan combined with quadruple therapy in the treatment of Helicobacter pylori(Hp)-related chronic atrophic gastritis(CAG).Method:A total of 96 patients with Hp-related CAG admitted to the Second Affiliated Hospital of Fujian Medical University from March 2022 to February 2023 were selected as the research objects.They were divided into control group(n=48)and observation group(n=48)according to the random number table method.The control group was given quadruple therapy,and the observation group was given Moluodan combined with quadruple therapy.The clinical efficacy,Hp-negative rate,traditional Chinese medicine syndrome score,quality of life instruments for chronic diseases-chronic gastritis(QLICD-CG)score and serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β),pepsinogen Ⅰ(PG-Ⅰ),pepsinogen Ⅱ(PG-Ⅱ)and ghrelin levels were compared between the two groups.Result:The total clinical effective rate of the observation group was 95.83%,higher than 83.33%of the control group,and the difference was statistically significant(P<0.05).The Hp-negative rate in the observation group was 100.00%,which was higher than 93.75%in the control group,but there was no statistically significant(P>0.05).After treatment,the traditional Chinese medicine syndrome score of the observation group was lower than that of the control group,and the QLICD-CG score was higher than that of the control group,the differences were statistically significant(P<0.05).After treatment,the serum levels of TNF-α,IL-6 and IL-1β in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum PG-Ⅰ and ghrelin in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Moluodan combined with quadruple therapy is effective in the treatment of Hp-related CAG,which can effectively inhibit inflammatory response,regulate PGⅠ and ghrelin levels,and improve clinical symptoms and quality of life of patients.
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