Intrahepatic cholestasis of pregnancy(ICP)is a common disease in the middle and late pregnancy,which poses a great threat to maternal and infant health.Although extensive studies have shown that the occurrence of the disease is closely related to immune,genetic,environmental and hormonal factors,its pathogenesis is still unclear.In recent years,the role of fibroblast growth factor(FGF)in the pathogenesis of ICP and whether it can be used as a biomarker of ICP have become a focus of research.In this paper,the relationship between FGF19 and FGF21 and the pathogenesis of ICP was discussed in terms of multiple metabolic mechanisms in vivo by searching relevant literatures of ICP and FGF.
关键词
妊娠期肝内胆汁淤积症/代谢/免疫平衡/应激/成纤维细胞生长因子
Key words
Intrahepatic cholestasis of pregnancy/Metabolism/Immune balance/Stress/Fibroblast growth factor
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