Analysis of Quantitative EEG and Blood Pressure Variability Changes and their Correlation with Cognitive Function in Parkinson's Patients
Objective:To analyze changes in quantitative EEG and blood pressure variability and their correlation with cognitive function in Parkinson's patients.Method:88 Parkinson's patients admitted to Yidu People's Hospital from June 2022 to October 2023 were selected as study subjects.Their cognitive functions were scored by using the Brief Mental State Exercise Scale(MMSE),and according to the scoring results,they were categorized into the cognitively impaired group(35 cases)and the non-cognitively impaired group(53 cases).The Parkinson's Disease Rating Scale(UPDRS)was used to compare the mental status,activities of daily living,motor examination,and motor complications between the two groups.Quantitative EEG(frontal,central,temporal,parietal,occipital)power spectrum coefficient and blood pressure variability(24 h mean systolic blood pressure and its standard deviation,24 h mean diastolic blood pressure and its standard deviation)were compared between the two groups.Correlations among quantitative EEG power spectral ratios,changes in blood pressure variability,and cognitive function were analyzed by using Person.Result:There was no statistically significant difference in the UPDRS scores of the two groups(P>0.05).The frontal,central,temporal,parietal,and occipital regions of patients in the cognitive impairment group were lower than those in the non-cognitive impairment group,and the difference was statistically significant(P<0.05).The result of person analysis showed that both quantitative EEG power spectral ratios and blood pressure variability correlated with cognitive function in Parkinson's patients.Conclusion:Both quantitative brainwave power ratio and blood pressure variability in Parkinson's patients who developed cognitive impairment were significantly different from those in Parkinson's patients who did not develop cognitive impairment,and there was a significant correlation between the above metrics and cognitive function in Parkinson's patients.
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