腹腔镜胆囊切除术中改良结扎法的临床应用效果及安全性
Clinical Efficacy and Safety of Modified Ligation Method in Laparoscopic Cholecystectomy
李宗倍 1吴畏 1安宏超 1李华志1
作者信息
摘要
目的:研究腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)中改良结扎法的临床应用效果及安全性.方法:选取 2022 年 1 月—2023 年 12 月北京市垂杨柳医院收治的 98 例LC患者.根据电脑编号奇偶数字法随机将其分为改良组(n=49)及传统组(n=49).改良组LC中实施改良结扎法,传统组LC中实施传统结扎法.比较两组围手术期指标,并发症,术前 1 d及术后 3 d肝功能指标、炎症因子.结果:改良组手术时长短于传统组,差异有统计学意义(P<0.05).两组腹腔出血、胆漏及切口感染发生率比较,差异无统计学意义(P>0.05).术后 3 d,两组丙氨酸转氨酶(alanine transaminase,ALT)、天冬氨酸转氨酶(aspartate transaminase,AST)及总胆红素(total bilirubin,TBIL)水平均高于术前 1 d,改良组ALT、AST、TBIL水平均低于传统组,差异有统计学意义(P<0.05).术后 3 d,两组白细胞介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)及C反应蛋白(C-reactive protein,CRP)水平均高于术前 1 d,改良组IL-6、PCT、CRP水平均低于传统组,差异有统计学意义(P<0.05).结论:改良结扎法应用于LC中安全可行,且能减轻对患者肝功能与炎症反应的影响.
Abstract
Objective:To study the clinical efficacy and safety of modified ligation method in laparoscopic cholecystectomy(LC).Method:A total of 98 patients with LC admitted to Beijing Chuiyangliu Hospital from January 2022 to December 2023 were selected.They were randomly divided into the improved group(n=49)and the traditional group(n=49)according to the computer numbering method.Modified ligation method was performed in the improved group in LC,and traditional ligation method was performed in the traditional group in LC.Perioperative indexes,complications,liver function indexes,inflammatory factors at 1 d before surgery and 3 d after surgery were compared between the two groups.Result:The operation time of the improved group was shorter than that of the traditional group,and the difference was statistically significant(P<0.05).There were no significant differences in the incidences of abdominal hemorrhage,bile leakage and incision infection between the two groups(P>0.05).At 3 d after surgery,the levels of alanine transaminase(ALT),aspartate transaminase(AST)and total bilirubin(TBIL)in the two groups were higher than those at 1 d before surgery,ALT,AST and TBIL levels in the improved group were lower than those in the traditional group,and the differences were statistically significant(P<0.05).At 3 d after surgery,the levels of interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)in both groups were higher than those at 1 d before surgery,the levels of IL-6,PCT and CRP in the improved group were lower than those in the traditional group,and the differences were statistically significant(P<0.05).Conclusion:The modified ligation method is safe and feasible in LC,and can reduce the impact on liver function and inflammation in patients.
关键词
腹腔镜胆囊切除术/改良结扎法/应用效果/安全性/炎症因子Key words
Laparoscopic cholecystectomy/Modified ligation method/Application effect/Security/Inflammatory factor引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据