Application of Oxycodone Combined with Sevoflurane in Laparoscopic Surgery for Gastrointestinal Cancer
Objective:To explore the application of Oxycodone combined with Sevoflurane in laparoscopic surgery for gastrointestinal cancer.Method:A total of 90 patients who undergoing laparoscopic surgery for gastrointestinal cancer in Fujian Cancer Hospital from August 2022 to August 2023 were selected as the research objects,the patients were divided into the control group and the observation group according to the different anesthetic drugs,45 cases in each group.The control group was anesthetized with Sevoflurane,while the observation group was anesthetized with Oxycodone combined with Sevoflurane.The recovery,pain,levels of inflammatory cytokines,and adverse reactions between the two groups were compared.Result:The spontaneous respiratory recovery time,extubation time and recovery time in the observation group were earlier than those in the control group,and the incidence of postoperative agitation was lower than that in the control group,the differences were statistically significant(P<0.05).The visual analogue scales(VAS)scores at 6 h,12 h and 24 h after operation of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Before anesthesia,there were no significant differences in the levels of interleukin-2(IL-2),interleukin-10(IL-10),interleukin-13(IL-13)and interferon-γ(INF-γ)between two groups(P>0.05);after operation,the levels of IL-2,IL-10,IL-13 and INF-γ in the two groups were higher than those before anesthesia,the levels of IL-2 and INF-γ in the observation group were lower than those in the control group,and the levels of IL-10 and IL-13 were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Oxycodone combined with Sevoflurane anesthesia can shorten the recovery time after anesthesia in patients undergoing laparoscopic surgery for gastrointestinal cancer,reduce postoperative pain,regulate the levels of inflammatory cytokines,and reduce adverse reactions.
OxycodoneSevofluraneLaparoscopic surgery for gastrointestinal cancerInflammatory cytokine
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