Effect of Tranexamic Acid Combined with Diagnostic Curettage in the Treatment of Abnormal Uterine Bleeding Perimenopausal
Objective:To explore the effect of Tranexamic Acid combined with diagnostic curettage in the treatment of abnormal uterine bleeding perimenopausal(AUBP).Method:A total of 90 patients with AUBP who treated in Beijing Huairou Hospital from June 2021 to June 2023 were selected as the study objects,and they were randomly divided into the control group(diagnostic curettage+Norethindrone)and the study group(diagnostic curettage+Tranexamic Acid),with 45 cases in each group.The clinical efficacy,hemoglobin(Hb),endometrial thickness,sex hormones[estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T)],inflammatory factors[interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)],vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)were compared between two groups.Result:The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,the Hb,VEGF and bFGF in two groups were higher than those before treatment,the endometrial thickness,E2,FSH,LH,T,IL-2 and TNF-α were lower than those before treatment,and the improvements in the study group were better than those in the control group,the differences were statistically significant(P<0.05).Conclusion:AUBP patients receiving Tranexamic Acid combined with diagnostic curettage treatment have significant therapeutic effects,which can reduce endometrial thickness,inflammatory factor levels,improve sex hormone,Hb levels,VEGF and bFGF.
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