Effects of Laparoscopic Regular Hepatic Lobectomy on Liver Function,Immune Function,Serum AFP and Hcy Levels in Patients with Primary Liver Cancer
Objective:To explore the effects of laparoscopic regular hepatic lobectomy on liver function,immune function,serum alpha-fetoprotein(AFP)and homocysteine acid(Hcy)levels in patients with primary liver cancer(PLC).Method:The clinical data of 200 patients with PLC who received surgical treatment in Guizhou Provincial People's Hospital from January 2019 to June 2023 were retrospectively analyzed.A total of 100 patients who underwent open surgery were selected as the control group,and 100 patients who underwent laparoscopic regular hepatic lobectomy were selected as the observation group.Changes in liver function[total bilirubin(TBIL),albumin(ALB),alanine transferase(ALT),aspartate aminotransferase(AST)],immune function(CD8+,CD4+,CD3+),inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]and serum AFP,Hcy levels were observed in the two groups after operation.Result:Before operation,there were no significant differences in liver function,immune function,inflammatory factors,serum AFP and Hcy levels between the two groups(P>0.05).After 1 d of surgery,ALB was higher than that before surgery in both groups,TBIL,ALT,AST,AFP and Hcy at 5 d after surgery were lower than those before surgery,and ALB in the study group was higher than that in the control group,TBIL,ALT,AST,AFP and Hcy were lower than those in the control group,the differences were statistically significant(P<0.05).After 5 d of surgery,the levels of TNF-α and IL-6 in the control group were higher than those before surgery,and the levels of CD8+,CD4+and CD3+were lower than those before surgery,the differences were statistically significant(P<0.05).After 5 d of surgery,the levels of TNF-α and IL-6 in the study group were lower than those in the control group,and the levels of CD8+,CD4+and CD3+were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Laparoscopic regular hepatic lobectomy can significantly reduce serum AFP and Hcy levels,reduce inflammatory factors,improve immunity and restore liver function in patients with primary liver cancer.
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