Correlation of 25-OH-D,WMR and NLR with the Degree of Coronary Artery Disease and In-hospital MACE in Female Patients with Early-onset Coronary Heart Disease
Objective:To investigate the correlation of 25-hydroxyvitamin D(25-OH-D),white blood cell count to mean platelet volume ratio(WMR)and neutrophil to lymphocyte ratio(NLR)and the degree of coronary artery disease and in-hospital major adverse cardiovascular events(MACE)in female patients with early-onset coronary heart disease.Method:A total of 200 female patients with coronary heart disease who admitted to People's Hospital of Ningxia Hui Autonomous Region from January 2020 to December 2021 were selected as the study group,the study group was divided into the early-onset group(age of onset of coronary heart disease≤65 years old,n=120)and the non-early-onset group(age of onset of coronary heart disease>65 years old,n=80)according to the age of onset,at the same time,200 healthy women with normal coronary angiography were selected as the control group.Gensini score was used to evaluate the severity of coronary artery disease,patients in the early-onset group were divided into the mild lesion group(≤30 scores),the moderate lesion group(31-60 scores)and the severe lesion group(>60 scores)according to Gensini score.The levels of 25-OH-D,WMR and NLR were detected in all patients,the levels of 25-OH-D,WMR and NLR in the control group,the early-onset group and the non-early-onset group were compared,the levels of 25-OH-D,WMR and NLR in the mild lesion group,the moderate lesion group and the severe lesion group were compared,the correlation between 25-OH-D,WMR,NLR and in-hospital MACE events was analyzed.Result:The WMR and NLR in the non-early-onset group were higher than those in the control group and the early-onset group,WMR and NLR in the early-onset group were higher than those in the control group,25-OH-D in the non-early-onset group was lower than that in the control group and the early-onset group,25-OH-D in the early-onset group was lower than that in the control group,the differences were statistically significant(P<0.05);the WMR and NLR in the severe lesion group were higher than those in the mild lesion group and the moderate lesion group,the WMR and NLR in the moderate lesion group were higher than those in the mild lesion group,25-OH-D in the severe lesion group was lower than those in the mild lesion group and the moderate lesion group,25-OH-D in the moderate lesion group was lower than that in the mild lesion group,the differences were statistically significant(P<0.05);correlation analysis showed that 25-OH-D was negatively correlated with Gensini score(r=-0.386,P<0.05),and WMR and NLR were positively correlated with Gensini score(r=0.674,0.621,P<0.05);all patients were followed up for 12-24 months,the average was(15.65±1.98)months,the patients were divided into the non-MACE group(85 cases)and MACE group(35 cases)according to whether MACE occurred in the early-onset group,the WMR and NLR in the MACE group were higher than those in the non-MACE group,and the 25-OH-D was lower than that in the non-MACE group,the differences were statistically significant(P<0.05);multifactor analysis showed that WMR and NLR were risk factors for MACE,and 25-OH-D was protective factor for MACE(P<0.05);according to receiver operating characteristic(ROC)curve analysis,the sensitivity and specificity of combined assessment of 25-OH-D,WMR and NLR were higher than those of single detection,and the value of combined assessment of MACE was higher.Conclusion:25-OH-D,WMR and NLR are significantly correlated with the degree of coronary artery disease and in-hospital MACE in female patients with early-onset coronary heart disease,which can provide an effective basis for the evaluation of the degree of coronary artery disease and in-hospital MACE in female patients with coronary heart disease.
Early-onset coronary heart disease25-hydroxyvitamin DRatio of white blood cell count to mean platelet volumeNeutrophil to lymphocyte ratio
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