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术前外周血炎症指标评价OSCC患者预后的研究进展

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口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是口腔颌面部最常见的恶性肿瘤之一,5 年生存率在综合治疗模式的发展完善下仍不理想.口腔部位组织因血液及淋巴丰富,有着易淋巴结转移及复发等特点,大量研究表明炎症和肿瘤息息相关,癌症相关炎症在肿瘤微环境及肿瘤的发生、发展阶段发挥重大作用,已有相关研究表明外周血炎症指标是多种恶性肿瘤的重要预后因子,本文通过检阅国内外相关文献分析术前外周血中性粒细胞/淋巴细胞比率(neutrophil-lymphocyteratio,NLR)、血小板/淋巴细胞比率(platelet to lymphocyteratio,PLR)、淋巴细胞/单核细胞比率(lymphocyte-to-monocyte ratio,LMR)、全身免疫炎症指数(systemic immune-inflammation index,SII)和全身炎症反应指数(systemic inflammation response index,SIRI)及C反应蛋白(C-reactive protein,CRP)预测OSCC预后的研究进展,以期为临床上选择综合治疗策略提供参考.
Research Progress of Preoperative Peripheral Blood Inflammation Index to Evaluate the Prognosis of OSCC Patients
Oral squamous cell carcinoma(OSCC)is one of the most common malignant tumors in oral and maxillofacial region.The 5-year survival rate is still not ideal despite the development and perfect of comprehensive treatment.Oral tissues are prone to lymph node metastasis and recurrence due to abundant blood and lymph.A large number of studies have shown that inflammation is closely related to tumors,and cancer-related inflammation plays an important role in tumor micro environment and the occurrence and development stage of tumors.Relevant studies have shown that peripheral blood inflammation indicators are important prognostic factors for a variety of malignant tumors.In this paper,the research progress of preoperative peripheral blood neutrophil/lymphocyteratio(NLR)and platelet to lymphocyte ratio(PLR),lymphocyte-to-monocyte ratio(LMR),systemic immune-inflammation index(SII),systemic inflammation response index(SIRI),and C-reactive protein(CRP)in predicting the prognosis of OSCC was analyzed by reviewing relevant literatures at home and abroad,in order to provide reference for clinical selection of comprehensive treatment strategies.

Peripheral blood inflammatory markersOral squamous cell carcinomaC-reactive proteinPrognosis

程龙龙、张诗涵、孟鑫、张静睿、周莹、王永功

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河南大学口腔医学院 河南 开封 475001

河南省人民医院

南阳市第二人民医院

外周血炎症指标 口腔鳞状细胞癌 C反应蛋白 预后

2024

中外医学研究
中国医院管理杂志社

中外医学研究

影响因子:1.149
ISSN:1674-6805
年,卷(期):2024.22(22)
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