Association of Novel Inflammatory Markers NLR,PLR,and MLR with Clinical Features of Gastric Adenocarcinoma in Young Adults
Objective:To investigate the association of preoperative neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),and monocyte/lymphocyte ratio(MLR)in young gastric adenocarcinoma patients with clinical features of young gastric adenocarcinoma.Method:The clinical data of 130 young patients(18～35 years old)with gastric adenocarcinoma admitted to the First Affiliated Hospital of Soochow University from January 2013 to December 2022 were retrospectively analyzed.Another 1348 normal physical examination subjects(18～35 years old)in the same period were selected as the control group.The levels of NLR,PLR and MLR were compared between the two groups.Spearman was used to analyze the correlation among NLR,PLR and MLR.Patients in the case group were divided into high and low groups according to the median PLR,MLR,and NLR.The relationship between high/low PLR,MLR,NLR and clinicopathologic features,gender,and clinical symptoms were analyzed,and evaluate their diagnostic value in gastric adenocarcinoma.Result:NLR and MLR,PLR and MLR,NLR and PLR were positively correlated(rs=0.738,0.630,0.665,P<0.001).There were no significant differences in T stage,N stage,M stage and TNM stage among patients with different NLR levels(P>0.05).There were significant differences in T stage,N stage and TNM stage among patients with different PLR levels(P<0.05).There was no significant difference in M stage among patients with different PLR levels(P>0.05).There was significant difference in M stage of patients with different MLR levels(P<0.05),There were no significant differences in T stage,N stage and TNM stage of patients with different MLR levels(P>0.05).There were statistical significance in gender of different NLR and PLR patients(P<0.05).There was no significant difference in gender between patients with different MLR levels(P>0.05).There were no significant differences between clinical symptoms and PLR,MLR and NLR levels(P>0.05).According to receiver operating characteristic(ROC)curve analysis,NLR,PLR and MLR had certain diagnostic efficacy in young gastric adenocarcinoma.Conclusion:Preoperative NLR,PLR,and MLR levels are closely related to the clinical features of young gastric adenocarcinoma,and can be used as a reference index for the early diagnosis of young gastric cancer.
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