Effect of Single-site Plus One-port Laparoscopic Surgery on Serum Tumor Marker Levels in Patients with Right-sided Colon Cancer
Objective:To observe the effect of single-site plus one-port laparoscopic surgery on serum tumor marker levels in patients with right-sided colon cancer.Method:A total of 112 patients with right-sided colon cancer who were admitted to the Dongping County People's Hospital from June 2018 to June 2023 were selected.According to the surgical method,the patients were divided into five-port group and single-site plus one-port group,with 56 patients in each group.The five-port group was treated with five-port laparoscopic surgery,while the single-site plus one-port group was treated with single-site plus one-port laparoscopic surgery.Surgery-related indicators,postoperative pain,serum tumor marker levels,and the incidence of complications were compared between the two groups.Result:The operation was successfully completed in both groups.The incision length,postoperative getting out of bed time,exhaust time and hospital stay in the single-site plus one-port group were shorter than those in the five-port group,and the differences were statistically significant(P<0.05).There were no significant differences in operation time and intraoperative blood loss between the two groups(P>0.05).The visual analog scale(VAS)scores of time,inter-group and interaction effects at 1 d,2 d and 3 d after surgery were compared,and the differences were statistically significant(P<0.05);the VAS scores of single-site plus one-port group were significantly lower than those of the five-port group at 1 d,2 d and 3 d after surgery,the differences were statistically significant(P<0.05).At 1 week after surgery,the levels of carcinoembryonic antigen(CEA)and carbohydrate antigen 199(CA199)in the single-site plus one-port group were significantly lower than those in the five-port group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the single-site plus one-port group and the five-port group(x2=1.757,P=0.185).Conclusion:Compared with the five-port method,single-site plus one-port laparoscopic surgery can shorten the length of incision and postoperative recovery time of patients with right-sided colon cancer,relieve pain,and lower serum CEA and CA199 levels.
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