Effect of Welsu Granules Combined with Magnesium Aluminum Carbonate and Omeprazole on Serum EGFR and ERK1/2 Levels in Patients with Gastric Ulcer Complicated with Bleeding
Objective:To investigate the effect of Gastrosu granules combined with magnesium aluminum carbonate and omeprazole on serum epidermal growth factor receptor(EGFR)and extracellular regulated protein kinase 1/2(ERK1/2)levels in patients with gastric ulcers(GU)complicated with bleeding.Method:A total of 248 patients with bleeding complicated by GU admitted to the Fifth Hospital of Xiamen City from March 2020 to March 2022 were selected as the study objects and divided into an observation group and a control group using simple randomized grouping,with 124 cases in each group.The patients in the control group were treated with magnesium aluminum carbonate and omeprazole,and the patients in the observation group were treated with Gastrosu granules on the basis of the control group,and both groups continued to be treated for 4 weeks.The clinical efficacy,serum EGFR,ERK1/2 levels,recovery-related indexes before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Result:After treatment,the total effective rate of treatment of patients in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum EGFR and ERK1/2 levels of patients in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the hospitalization time,abdominal pain and distension,acid reflux,belching,vomiting blood and black stool improvement time of patients in the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the occurrence of adverse reactions such as dry mouth,diarrhea,nausea and vomiting,dizziness and other adverse reactions in the two groups were compared,and the difference was not statistically significant(P>0.05).Conclusion:The efficacy of Gastrosu granules combined with magnesium aluminum carbonate and omeprazole in the treatment of patients with GU complicated with bleeding is precise,which can improve expression of serum EGFR and ERK1/2,and has a high therapeutic safety.
WeIsu granulesMagnesium aluminum carbonateOmeprazoleGastric ulcer complicated with bleeding