Effect of Jianxin Granules Combined with Western Medicine in the Treatment of Elderly Patients with CHF
Objective:To explore the effect of Jianxin Granules combined with western medicine in the treatment of elderly patients with chronic heart failure(CHF).Method:According to the random coin-operated method,70 elderly patients with CHF who treated in the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January to December 2022 were divided into the control group(n=35)receiving conventional western medicine treatment and the observation group(n=35)receiving Jianxin Granules combined with western medicine treatment,the clinical efficacy,cardiac function,myocardial remodeling,symptoms of heart failure and exercise endurance of two groups were compared.Result:After 2 months of treatment,the total effective rate of the observation group were higher than that of the control group,the difference was statistically significant(P<0.05);after 2 months of treatment,the left ventricular ejection fraction and 6-minute walking test in the two groups were higher than those before treatment,and those in the observation group were higher than the control group,the interventricular septal end-diastolic thickness,left ventricular end-diastolic diameter,left ventricular end-systolic diameter,N-terminal pro-brain natriuretic peptide,serum chemokine,soluble growth stimulation expressed gene 2(sST2)level and Lee's heart failure score in two groups were lower than those before treatment,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion:Jianxin Granules combined with western medicine can inhibit the expression of myocardial remodeling indexes such as sST2 and serum chemokines in elderly patients with CHF,which can significantly improve the exercise tolerance and cardiac function and improve the symptoms of heart failure,which is conducive to the improvement of clinical efficacy.
万方数据
维普
