Effect of Sackubactril Valsartan Sodium on Maintenance Hemodialysis Complicated with Chronic Heart Failure
Objective:To explore the effect of Sacubitril Valsartan Sodium on maintenance hemodialysis patients complicated with chronic heart failure(CHF).Method:A total of 88 patients with maintenance hemodialysis complicated with CHF admitted to the Nephrology Department of Liupanshui People's Hospital from September 2020 to September 2023 were selected as the study subjects.They were randomly divided into two groups,with 44 patients in each group according to random number table method.Both groups received routine symptomatic treatment and hemodialysis treatment.The control group received Irbesartan treatment,while the observation group received Sacubitril Valsartan Sodium.The clinical efficacy,inflammatory factors,heart function,quality of life,and adverse events between two groups were compared.Result:The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),left ventricular end-diastolic diameter(LVEDd),N-terminal B-type natriuretic peptide precursor(NT-proBNP)and Minnesota heart failure quality of life table(MLHFQ)indexes in the observation group were lower than those in the control group,the index of left ventricular ejection fraction(LVEF)was higher than that of control group,the differences were statistically significant(P<0.05).The incidence of adverse events in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion:The application of Sacubitril and Valsartan Sodium in maintenance hemodialysis patients with CHF has a definite effect,can promote the improvement of heart function,reduce the body's inflammatory response,reduce the occurrence of adverse events,and help improve the quality of life.
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